UK reported its biggest one-day Covid case increase in 3 months just as the new delta variant AY.4 with the S:Y145H mutation in the spike reaches 8% of UK sequenced cases. We need urgent research to figure out if this delta plus is more transmissible, has partial immune evasion.
Translating into plain English, what’s this mean? Delta is a variant of SARS-CoV-2. AY4 is a subvariant derived from delta and AY4 S:Y145H is a subsub variant in which the spike gene (S) is mutated from a tyrosine (Y) at position 145 to a histidine (H)